BEST SELLER! This combination of B vitamins has been proven to reduce plaque formation in the arteries. It uses the methylated forms of the B vitamins, so there is no need for their conversion in the liver. The sublingual tablet dissolves under the tongue and gets absorbed directly into the bloodstream, bypassing the digestive process altogether. The high dose B12 gives extra energy and endurance. Great for those with the MTHFR gene mutation.